The NFL is set to drop the full 2025 regular season schedule tonight, giving Cardinals fans their first look at how Arizona’s season will stack up week by week — including when the toughest matchups will hit and whether the national spotlight will follow.
After a rebuilding 2024 campaign that saw flashes of promise under quarterback Kyler Murray, Arizona enters the new season with renewed expectations and a roster full of young talent. The opponents have been locked in since the end of last year, but now it’s about timing — and how the Cardinals navigate one of the more difficult schedules in the league.
Arizona Cardinals’ 2025 opponents
Home games: Los Angeles Rams, San Francisco 49ers, Seattle Seahawks, Atlanta Falcons, Carolina Panthers, Jacksonville Jaguars, Tennessee Titans, Green Bay Packers
Road games: Rams, 49ers, Seahawks, Houston Texans, Indianapolis Colts, Tampa Bay Buccaneers, New Orleans Saints, Dallas Cowboys, Cincinnati Bengals
Arizona Cardinals 2025 full schedule
Week 1: at New Orleans Saints — Sunday, Sept. 7 at 1 p.m. (CBS)
Week 2: vs. Carolina Panthers — Sunday, Sept. 14 at 4:05 p.m. (CBS)
Week 3: at San Francisco 49ers — Sunday, Sept. 21 at 4:25 p.m. (Fox)
Week 4: vs. Seattle Seahawks (Thursday Night Football) — Thursday, Sept. 25 at 8:15 p.m. (Prime Video)
Week 5: vs. Tennessee Titans — Sunday, Oct. 5 at 4:05 p.m. (CBS)
Week 6: at Indianapolis Colts — Sunday, Oct. 12 at 1 p.m. (Fox)
Week 7: vs. Green Bay Packers — Sunday, Oct. 19 at 4:25 p.m. (Fox)
Week 8: BYE
Week 9: at Dallas Cowboys (Monday Night Football) — Monday, Nov. 3 at 9:15 p.m. (ESPN/ABC)
Week 10: at Seattle Seahawks — Sunday, Nov. 9 at 4:05 p.m. (CBS)
Week 11: vs. San Francisco 49ers — Sunday, Nov. 16 at 4:05 p.m. (Fox)
Week 12: vs. Jacksonville Jaguars — Sunday, Nov. 23 at 4:05 p.m. (Fox)
Week 13: at Tampa Bay Buccaneers — Sunday, Nov. 30 at 1 p.m. (Fox)
Week 14: vs. Los Angeles Rams — Sunday, Dec. 7 at 4:25 p.m. (Fox)
Week 15: at Houston Texans — Sunday, Dec. 14 at 1 p.m. (Fox)
Week 16: vs. Atlanta Falcons — Sunday, Dec. 21 at 4:05 p.m. (Fox)
Week 17: at Cincinnati Bengals — TBD
Week 18: at Los Angeles Rams — TBD
Cardinals 2025 strength of schedule
According to Sharp Football Analysis, the Cardinals face the 11th-toughest schedule in the NFL based on projected win totals — the hardest slate among any team in the NFC West. With road games against contenders like the Bengals, Cowboys, and 49ers, Arizona will be tested early and often.