The Arizona Cardinals have an injury concern with running back James Conner in the second half of the Week 3 game against the San Francisco 49ers.
Conner got injured in the third quarter of the contest and was later carted off the field. It appears he's dealing with an ankle injury and it might be serious.
Conner was surrounded by teammates after he went down and there was clear concern for him.
Prior to his exit, Conner had nine carries for 22 yards and three catches for 15 yards. He'll be replaced by Trey Benson as long as he's out.
Here's the latest updates on Conner's status for the rest of the game.
James Conner injury update
UPDATE: Conner has already been ruled out with an ankle injury, which is yet another sign he is dealing with something significant.
#Cardinals RB James Conner, who was carted off moments ago, has already been ruled out with an ankle injury.
— Tom Pelissero (@TomPelissero) September 21, 2025
END OF UPDATE
As we previously noted, Conner was carted off the field, which is not a good sign. He is dealing with an apparent ankle injury but that hasn't been confirmed.
James Conner suffered an apparent right ankle injury and is being carted off. https://t.co/TyOj1KVqZe
— Adam Schefter (@AdamSchefter) September 21, 2025
Here's the play where Conner got hurt.
WAY too many injuries today...Cardinals RB James Conner is being carted off the field after being tackled very awkwardly.
— Arye Pulli (@AryePulliNFL) September 21, 2025
The broadcast did not show the replay-- very telling of the severity of the injury. pic.twitter.com/Qpi26CUrrX
We'll update his page once more information becomes available.
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