We are two matches into the 2025/26 Serie A season and there is a lot to look forward to as the Campeonato in Italy sees Napoli seeking to defend their title.
Antonio Conte led the Neapolitans to their fourth Scudetto last season, but the former Juventus and Chelsea boss will have to balance domestic commitments with a UEFA Champions League run this season; something he has always struggled to do.
That will give hope to the chasing pack despite Napoli's flying start as AC Milan and Inter Milan embark upon new eras with Cristian Chivu and Massimiliano Allegri now in situ at San Siro.
Elsewhere, Maurizio Sarri has returned to Lazio, Gian Piero Gasperini has moved from Atalanta to Roma and Igor Tudor begins the campaign under immediate pressure at Juventus.
Drama and entertainment is to be expected throughout in what is arguably Europe’s most fascinating and competitive league. The Sporting News brings you a betting guide with the latest tips and odds for title winner, relegation, top goalscorer and top 4 finish.
MORE: Latest football news from Serie A and other top leagues | Full football fixtures | Serie A table 2025/26
Serie A predictions 2025/26: Title winner
Four teams have won their first two matches, including defending champions Napoli who remain the favourites to win the Serie A title once again, with the signings of Sam Beukema, Kevin De Bruyne, Noa Lang and Lorenzo Lucca giving Conte a lot more firepower to fight on all fronts.
Cremonese have been the surprise quick starter after two wins and two draws rom their opening four games, including an away win at AC Milan. Lazio have drifted to 150/1 after taking just three points so far.
| Team | Odds |
| Napoli | 5/4 |
| AC Milan | 7/2 |
| Inter | 4/1 |
| Roma | 7/1 |
| Juventus | 8/1 |
| Atalanta | 80/1 |
| Como | 80/1 |
| Fiorentina | 125/1 |
Serie A predictions 2025/26: Relegation candidates
Two of last season’s promoted teams are expected to be relegated according to the odds, with Cremonese — even after their surprise start — and Pisa, now the home of Juan Cuadrado, both expected to struggle this season.
The other promoted side, Sassuolo, should never really have gone down in the first place and the Domenico Berardi-captained Neroverdi may have enough to ease themselves into the mid-table spots.
| Relegation odds | |
|---|---|
| Pisa | 8/15 |
| Verona | 1/1 |
| Lecce | 5/4 |
| Cremonese | 7/4 |
| Sassuolo | 2/1 |
| Parma | 5/2 |
| Genoa | 4/1 |
| Cagliari | 5/1 |
| Torino | 6/1 |
Serie A predictions 2025/26: Capocannoniere top scorer
The top goalscorer is an interesting market in any top division. In Italy, the Capocannoniere is Serie A’s top scorer award. Mateo Retegui was the top scorer last season but the Italy international has since moved to Al Qadsiah.
Inter striker Lautaro Martinez was the early favourite, with the 2022 FIFA World Cup winner developing and maturing into one of the very best players in the world in recent years. Who has usurped him at the top of the market?
Jonathan David has joined Juve on a free transfer from Lille, and he will be expected to be up there, with Moise Kean likely to continue his good form for Fiorentina.
Lorenzo Lucca has a real chance, too, following Romelu Lukaku's injury. He will hope to profit from the service expected to be provided by De Bruyne.
| Top scorer odds | |
|---|---|
| Marcus Thuram | 5/1 |
| Lautaro Martinez | 13/2 |
| Rasmus Hojlund | 10/1 |
| Jonathan David | 10/1 |
| Dusan Vlahovic | 16/1 |
Serie A predictions 2025/26: Top four contenders
The aforementioned title race teams will be expected to be in the top four, but they all have their fallibilities and concerns, potentially opening the door for other contenders such as Roma, who poached Gasperini after the magnificent work he did at Atalanta.
Ivan Juric in at Atalanta, following his relegation with Southampton last season, is expected to contribute to a natural regression from the Bergamasci, and Sarri will be hoping that his settled Lazio side, as a result of a transfer ban, could prove to be a blessing in disguise.
The one team to keep an eye out for this season will be Cesc Fabregas’ Como, who gained promotion in the 2023/24 season and finished last season exceptionally well. The Spaniard has been heavily financially backed in the summer transfer window, too.
| Top four odds | |
|---|---|
| Napoli | 1/10 |
| Inter Milan | 4/11 |
| Juventus | 5/11 |
| AC Milan | 8/13 |
| Roma | 5/4 |
| Atalanta | 7/2 |
| Como | 5/1 |
When is the start and end date of the Serie A season 2025/26?
The 2025/26 Serie A season got underway on Saturday, August 23. Serie A likes to stagger the final day of the season so a defined date is not yet in place, but the season will end across the weekend of May 23/24.
How to watch the Serie A 2025/26 season
For the 2025/26 Serie A season in the U.K., you can watch every match live on DAZN, which holds the exclusive streaming rights for all Serie A games in the country.
Additionally, select matches will also be available on TNT Sports 1 and TNT Sports 2 for TV viewing.
For those who prefer digital platforms, matches can be streamed online on Discovery+ with a valid subscription, and some free games will be available via the One Football app and website. Highlights are available on DAZN as well.