Two unbeaten NFC West sides, 49ers and the Cardinals will face off in a Week 3 divisional matchup of the 2025 NFL season on Sunday at Levi's Stadium.
Arizona defeated the Panthers in a narrow 27-23 win, while San Francisco won their second game on the road, beating the Saints 26-21. The 49ers will next play in their home opener this weekend.
The 49ers currently lead the all-time series 36-31-0 and hold a 3-2 advantage in their last five meetings. The Cardinals, however, have won the previous two matchups: 47-24 at home in 2025 and a 24-23 thriller at Santa Clara in 2024.
Arizona has opened the season 2–0 despite failing to top 300 yards of offense in either game. San Francisco will still be wary of quarterback Kyler Murray, who has given the 49ers' defense problems in the past, including a career-best 84 rushing yards against them last year.
Here is everything you need to know about 49ers vs. Cardinals, including TV and streaming options for the game.
MORE: Full NFL TV coverage map for Week 3 games
What channel is 49ers vs. Cardinals on today?
- Local TV channels: KTVU channel 2 (San Francisco), KSAZ channel 10 (Phoenix)
- Out-of-market TV channel: Fox
- Live stream: Fubo
The 49ers vs. Cardinals game will air nationally on Fox. Local fans in San Francisco can watch on KTVU (channel 2), while those in Phoenix can tune in on KSAZ (channel 10)
49ers vs. Cardinals will air on CBS nationally. Football fans can also stream the game on Fubo.
Adam Amin and Mark Sanchez will be on the call for FOX. Kristina Pink will be the sideline reporter for 49ers vs. Cardinals.
49ers vs. Cardinals start time
- Date: Sunday, Sep. 21
- Time: 4:25 p.m. ET | 1:25 p.m. PT
49ers vs. Cardinals will kick off at 4:25 p.m. ET on Sunday, Sep. 21. The game will be played at Levi's Stadium in Santa Clara, California.
49ers vs. Cardinals radio station
- Radio channel: SiriusXM channel 227 (home) and 382 (away)
You can listen to the 49ers vs. Cardinals on SiriusXM. Coverage will be available on channel 227 (San Francisco 49ers broadcast) and channel 382 (Arizona Cardinals broadcast)
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San Francisco 49ers schedule 2025
Here's the 49ers' 2025 NFL regular season schedule.
| Week | Date | Opponent | Kickoff time (ET) | TV channel |
| 1 | Sunday, Sept. 7 | Seahawks 13, 49ers 17 | --- | --- |
| 2 | Sunday, Sept. 14 | Saints 21, 49ers 26 | --- | --- |
| 3 | Sunday, Sept. 21 | vs. Cardinals | 4:25 p.m. | Fox |
| 4 | Sunday, Sept. 28 | vs. Jaguars | 4:05 p.m. | Fox |
| 5 | Thursday, Oct. 2 | at Rams | 8:15 p.m. | Prime Video |
| 6 | Sunday, Oct. 12 | at Buccaneers | 1 p.m. | CBS |
| 7 | Sunday, Oct. 19 | vs. Falcons | 8:30 p.m. | NBC |
| 8 | Sunday, Oct. 26 | at Texans | 1 p.m. | Fox |
| 9 | Sunday, Nov. 2 | at Giants | 1 p.m. | CBS |
| 10 | Sunday, Nov. 9 | vs. Rams | 4:25 p.m. | Fox |
| 11 | Sunday, Nov. 16 | at Cardinals | 4:05 p.m. | Fox |
| 12 | Monday, Nov. 24 | vs. Panthers | 8:15 p.m. | ESPN |
| 13 | Sunday, Nov. 30 | at Browns | 1 p.m. | CBS |
| 14 | BYE | — | — | — |
| 15 | Sunday, Dec. 14 | vs. Titans | 4:25 p.m. | Fox |
| 16 | Monday, Dec. 22 | at Colts | 8:15 p.m. | ESPN |
| 17 | Sunday, Dec. 28 | vs. Bears | 8:20 p.m. | NBC |
| 18 | TBD | vs. Seahawks | TBD | TBD |
Arizona Cardinals schedule 2025
Here's the Cardinals' 2025 NFL regular season schedule.
| Week | Date | Opponent | Kickoff time (ET) | TV channel |
| 1 | Sunday, Sept. 7 | Saints 13, Cardinals 20 | --- | --- |
| 2 | Sunday, Sept. 14 | Cardinals 27, Panthers 22 | --- | --- |
| 3 | Sunday, Sept. 21 | at 49ers | 4:25 p.m. | Fox |
| 4 | Thursday, Sept. 25 | vs. Seahawks (TNF) | 8:15 p.m. | Prime Video |
| 5 | Sunday, Oct. 5 | vs. Titans | 4:05 p.m. | CBS |
| 6 | Sunday, Oct. 12 | at Colts | 1 p.m. | Fox |
| 7 | Sunday, Oct. 19 | vs. Packers | 4:25 p.m. | Fox |
| 8 | BYE | — | — | — |
| 9 | Monday, Nov. 3 | at Cowboys (MNF) | 9:15 p.m. | ESPN/ABC |
| 10 | Sunday, Nov. 9 | at Seahawks | 4:05 p.m. | CBS |
| 11 | Sunday, Nov. 16 | vs. 49ers | 4:05 p.m. | Fox |
| 12 | Sunday, Nov. 23 | vs. Jaguars | 4:05 p.m. | Fox |
| 13 | Sunday, Nov. 30 | at Buccaneeers | 1 p.m. | Fox |
| 14 | Sunday, Dec. 7 | vs. Rams | 4:25 p.m. | Fox |
| 15 | Sunday, Dec. 14 | at Texans | 1 p.m. | Fox |
| 16 | Sunday, Dec. 21 | vs. Falcons | 4:05 p.m. | Fox |
| 17 | TBD | at Bengals | TBD | TBD |
| 18 | TBD | at Rams | TBD | TBD |
NFL schedule 2025: Week 3
Here's a complete look at the NFL schedule for Week 3 of the new season, with games spread out across three days.
Thursday, Sept. 18
| Game | Time (ET) | TV/Live stream |
|---|---|---|
| Dolphins vs. Bills | 8:15 p.m. | Prime Video |
Sunday, Sept. 21
| Game | Time (ET) | TV/Live stream |
|---|---|---|
| Packers vs. Browns | 1 p.m. | Fox, Fubo |
| Colts vs. Titans | 1 p.m. | CBS, Fubo |
| Bengals vs. Vikings | 1 p.m. | CBS, Fubo |
| Steelers vs. Patriots | 1 p.m. | CBS, Fubo |
| Rams vs. Eagles | 1 p.m. | Fox, Fubo |
| Jets vs. Buccaneers | 1 p.m. | Fox, Fubo |
| Raiders vs. Commanders | 1 p.m. | Fox, Fubo |
| Falcons vs. Panthers | 1 p.m. | Fox, Fubo |
| Texans vs. Jaguars | 1 p.m. | CBS, Fubo |
| Broncos vs. Chargers | 4:05 p.m. | CBS, Fubo |
| Saints vs. Seahawks | 4:05 p.m. | CBS, Fubo |
| Cowboys vs. Bears | 4:25 p.m. | Fox, Fubo |
| Cardinals vs. 49ers | 4:25 p.m. | Fox, Fubo |
| Chiefs vs. Giants | 8:20 p.m. | NBC, Fubo |
Monday, Sept. 22
| Game | Time (ET) | TV/Live stream |
|---|---|---|
| Lions vs. Ravens | 8:15 p.m. | ABC, ESPN, Fubo |